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Specifically, semaglutide reduced total fat mass and visceral fat mass (generally considered to be unhealthy fat) and increased the proportion of lean body mass in adults with overweight or obesity

The McCoy 2013 paper extended this work by introducing N- and C-terminal modifications designed to enhance metabolic stability and hydrophobicity, ultimately producing Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) as an orally active, BBB-permeable analog [2]

Common side effects include injection site reactions, gastrointestinal disturbances, headache, and chromaturia

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The peptide upregulates genes involved in collagen synthesis, including COL1A1 (Type I collagen), COL3A1 (Type III collagen), and COL4A1 (Type IV collagen)