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To rule out the possibility that lean mass loss following BW reduction could have affected creatinine-based eGFR measurement, the muscle mass-independent endogenous filtration marker cystatin C was used to confirm the renal favorable effects attributed to tirzepatide [52]

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J Recept Signal Transduct Res (2013) 33(4):21323.10.3109/10799893.2013.802805 38 PalazzoMBalsariARossiniASelleriSCalcaterraCGariboldiSet alActivation of enteroendocrine cells via TLRs induces hormone, chemokine, and defensin secretion

Another program, the Semaglutide Treatment Effect in People with Obesity (STEP) program, found that after 68 weeks (approximately 16 months) of taking a 2.4 mg dose of semaglutide, participants achieved an average weight loss of 14.9% from baseline