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Animal Model Evidence The systemic evidence base is entirely preclinical: Pulmonary fibrosis (mouse model): Intraperitoneal GHK-Cu at 0.2-20 micrograms/g/day protected against bleomycin-induced lung fibrosis by inhibiting TGF-beta1/Smad signaling and reducing oxidative stress (PMID 31809714)

In brief, lipid peroxidation forms toxic lipid free radicals and serves as a trigger for ferroptosis, especially when excess iron ions exist in the cytoplasm

doi:10.1007/BF02785352

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