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Similarly, Shah et al

Lepore JJ, Olson E, Demopoulos L et al (2016) Effects of the novel long-acting GLP-1 agonist, albiglutide, on cardiac function, cardiac metabolism, and exercise capacity in patients with chronic heart failure and reduced ejection fraction

As soon as the tissue is reperfused with blood, the xanthine oxidase is suddenly presented with oxidizable substrate in the form of xanthine/hypoxanthine and starts to generate copious amounts of ROS

This might not be translated in view of the clinical reality where degenerative IVD processes are chronic and established over a timeperiod of years before the treatment will be applied

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