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Compared with baseline, there was a significant reduction in migraine attack frequency, headache severity, and number of headache days in those taking lipoic acid, while those taking placebo experienced no change
Systemic pre-treatment with a group II mGlu agonist, LY379268, reduces hyperalgesia in vivo
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However, as our understanding of cell signaling and regulatory pathways has developed, so has the involvement of GSH homeostasis in many other key processes, including regulation of cell proliferation and apoptosis and post-transcriptional modification of proteins through S-glutathionylation
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