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doi: 10.1210/jcem-19-1-45 100 YamadaTIkejiriKKotaniMKusakabeT

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Figure 2: Novel Incretin Mimetic Assets for T2DM and Obesity in Phase 2/3 of Development Remaining Unmet Needs Remaining Unmet Needs Though the value proposition of on-market GLP-1 and dual-agonists is strong, several key unmet needs still exist for incretin mimetics across diabetes and obesity, namely: (1) improved efficacy, (2) better tolerability, (3) more convenient options / alternative ROAs, and (4) improved access and affordability

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Rare side effects may include mild nausea or an allergic reaction

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Aconiti Lateralis radix Praeparata lipid-soluble alkaloids alleviates IL-1-induced inflammation of human fibroblast-like synoviocytes in rheumatoid arthritis by inhibiting NF-B and MAPKs signaling pathways and inducing apoptosis

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