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doi:10.2147/CCID.S128339 Watanabe F, Hashizume E, Chan GP, Kamimura A

RNA sequencing and pathway enrichment analysis show FOXO4-DRI significantly downregulates extracellular matrix-receptor interaction pathways, including fibronectin (Fn1), tenascin C (Tnc), and thrombospondin 2 (Thbs2), all critical components of fibrotic tissue architecture

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Research focuses on effects of increased endogenous GH release without administering exogenous hormones