Compared to the free drug, in vitro and in vivo assays showed that gold nanoparticle-conjugated quercetin inhibited angiogenesis and invasion of breast cancer by targeting the EGFR/VEGFR-2 signaling pathway ( in vitro and in vivo anti-angiogenic activity in a breast cancer model that was mediated by suppressing VEGF in cancer cells (Shashni et al., 2021)
Otvos, L.J., Cudic, M., Chua, B.Y., Deliyannis, G., and Jackson, D.C., Mol
Figure 1 2.3 Lipid antioxidant system in RA When lipid peroxides accumulate, cells can resist oxidation and prevent ferroptosis through various regulatory mechanisms, the most important of which is the antioxidant regulatory system composed of the cystine/glutamate antitransporter (System Xc-) and phospholipid hydroperoxidase glutathione peroxidase 4 (GPX4) ( With the progress of research, in addition to the GPX4 antioxidant pathway, three other new pathways unrelated to GPX4 in ferroptosis have been identified: ferroptosis inhibition protein 1 (FSP1)/CoQ10, GTP cyclic hydrolase 1 (GCH1)/tetrahydrobiopterin (BH4), and dihydroorotate dehydrogenase (DHODH)
is currently employed as a Chief Scientist by AstraZeneca Biopharmaceuticals R&D, Translational Science and Experimental Medicine (TSEM), and Early Cardiovascular, Renal and Metabolism (eCVRM), Cambridge, UK
December 2025: Emcure Pharmaceuticals launched Poviztra, a semaglutide-based weight-loss therapy, at USD 106 (INR 8,790) per month, becoming the first Indian company to commercialize Novo Nordisks molecule for obesity
