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It can lead to neuropathy, megaloblastic anemia, and pernicious anemia, [2] [13] causing symptoms including fatigue, paresthesia, depression, cognitive decline, ataxia, and even irreversible nerve damage

WB detected increased Bcl-2 and decreased Bax protein levels in DPCs

For every batch we perform size exclusion chromatography (SEC) to monitor aggregates

Response: We appreciate the comment for their general support of the inclusion of third-party intermediaries in the ASM data submission mechanisms

These types of therapies therefore generally require high doses and long treatment durations, which increase the risk of undesirable side effects