Given that critical protective and detoxifying role, it is not surprising that more than 25% of the bodys glutathione is found in the liver with high levels also present in the kidneys, lungs, adrenal glands, reproductive organs, brain and pancreas
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In environments where endogenous glutathione is severely depletedsuch as during a massive inflammatory flare, a viral cytokine storm, or an MCAS reactionthe free sulfhydryl group (-SH) on the NAC molecule allows it to act as a direct scavenger
The second one determines deformability as the hemolysis resistance of the RBCs population