Ethics statement The studies involving human participants were reviewed and approved by the Ethics Committee of Shanghai Municipal Hospital of Traditional Chinese Medicine
Oxid Med Cell Longev 2023(1):3400147 Zheng H, Jiang L, Tsuduki T, Conrad M, Toyokuni S (2021) Embryonal erythropoiesis and aging exploit ferroptosis
and Bifidobacterium infantis, which supports overall microbiome balance and gut barrier function
Further research is required to fully elucidate the KEAP1-dependent and -independent mechanisms of GSH-dependent regulation of NRF2
Consider: Baseline blood pressure and heart rate measurement before starting combination therapy Regular monitoring during dose titration of either medication Prompt evaluation of palpitations, chest pain, or shortness of breath Caution in patients with pre-existing cardiovascular disease , including coronary artery disease, arrhythmias, or uncontrolled hypertension ECG evaluation if indicated by clinical history or symptoms Nutritional adequacy must be maintained