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Dose-response relationships in terms of insulin levels in tail plasma are apparent for both routes of application (Figure 8)

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We can also expect more guidelines on weight management and management of kidney disease using incretin therapy, and clinical studies may show beneficial effects of the early introduction of combination therapy on the long-term control of blood glucose levels

The dose-response meta-analysis showed that higher doses of GLP-1 RAs were associated with increased risks of nausea, vomiting, diarrhea, constipation, and decreased appetite