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Specifically, elevated pyroglutamic acid and L-phenylalanine levels characterized SLE patients, while taurine accumulation marked LN, indicating their potential as stage-specific biomarkers [53]

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Parenteral administration of minute amounts of endotoxins to humans elicits an inflammatory reaction typical of SIRS (fever or hypothermia, tachycardia, hyperpnea, leukocytosis, and hypotension), whereas larger amounts of administered endotoxins typically produce sepsis and shock [66, 67]