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During this process, epithelial cells gradually lose their cobblestone epithelial appearance in monolayer cultures, along with cell-cell contact and adhesion capacity, and convert into a spindle-shaped mesenchymal phenotype that is more motile [80, 81]

doi: 10.1016/j.mayocpiqo.2019.03.002

Proteins with a fold change (FC) 1.5 or FC 0.6667, coupled with a P -value 0.05, were defined as significantly differential proteins (DEPs)

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Some research indicates the therapeutic value in going through a k-hole experience, while others have shown therapeutic value without that being necessary