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In extreme cases, unmanaged dehydration and electrolyte derangement can trigger cardiac arrhythmias or acute pancreatitis

Kobori M, Takahashi Y, Sakurai M, Ni Y, Chen G, Nagashimada M, Ota T (2017) Hepatic transcriptome profiles of mice with diet-induced nonalcoholic steatohepatitis treated with astaxanthin and vitamin E

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A secondary analysis of this metric was completed after stratifying patients by overweight status

Given that GLP-1 RAs result in weight loss and the pronounced effects of weight loss on haemodynamic disturbance and cardiac reverse remodelling in obese HF patients, the question is, to what extent is the effect of the drugs related to a direct effect on the cardiovascular system in HF