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Sustained IGF-I elevation from any GH secretagogue raises theoretical concerns IGF-I is a mitogen, and chronic elevation is a variable of interest in tissue-growth contexts that have not been evaluated for this blend over time

~10 min IGFBP affinity reduction / ~1,000-fold lower than native IGF-1 Primary receptor / IGF-1R (Kd ~1 nM)

Most patients tolerate treatment very well

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Can tesamorelin reduce visceral fat