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Description

Why was AOD 9604 development discontinued

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Wyss, M

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Various enzyme systems such as cytochrome P450, the mitochondrial respiratory chain, xanthine oxidase (XO), uncoupled endothelial nitric oxide synthase (eNOS), heme oxygenase (HO), myeloperoxidase (MPO), lipoxygenase (LOX), cyclooxygenase (COX) and NADPH oxidases (NOX) generate ROS especially in a pathological state [51]

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PGC-1 is a pivotal regulator of mitochondrial biogenesis and mitophagy (Palikaras and Tavernarakis, 2014)

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