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Levels naturally decline with age, which has fuelled interest in whether supplementation can reverse age-related tissue changes

In doing so, it deviates the production and action of the enzyme tyrosinase, an enzyme involved with melanin synthesis

10.1016/0306-9877(94)90071-X [DOI] [PubMed] [Google Scholar] Rutter J, Reick M, Wu LC, McKnight SL (2001) Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors

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In addition, 2-fucosyllactose (2-FL), a prebiotic, exhibited preventive effects against OP in a naturally aging mouse model by maintaining the diversity and composition of the GM, the gut barrier function, and the innate immune system (267)