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high proportions of patients achieve sustained low disease activity or remission One of the major pitfalls of biologic TNF inhibition is the occurrence of infectious complications (common or opportunistic) Other shortcomings of current anti-TNF biologics include high costs, inadequate numbers of treated patients achieving sustained, high-magnitude responses or remission and secondary loss of efficacy over time This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 12 print issues and online access $189.00 per year only $15.75 per issue Buy this article Purchase on SpringerLink Instant access to the full article PDF