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GHK-Cu, or copper tripeptide-1, is a small, skin-permeable peptide consisting of glycine, histidine, and lysine bound to copper

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It is unlike most antioxidants in that it is created in the liver

On the other hand, a significant increase in TDO expression has been found in preeclampsia, but since inflammatory response is involved in the pathogenesis of preeclampsia, it can be hypothesized that upregulation of TDO cannot fully compensate for the decrease in IDO in this regard

This means these substances must be prescribed by a registered medical practitioner