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Overall, individual responses to the medication vary, which accounts for some of the differences seen across available studies

Tirzepatide: A novel glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 receptor agonist for the treatment of type 2 diabetes: The first Twincretin

This reinforces that while retatrutide mood changes are a hot topic on social media, the clinical data suggests these medications are generally safe for mental health when used under medical supervision

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It also inhibits glucagon secretion from pancreatic alpha-cellsfurther contributing to glucose control