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It is released from the extracellular matrix during tissue injury specifically cleaved from SPARC (Secreted Protein Acidic and Rich in Cysteine) and the alpha 2(I) chain of type I collagen.[2] Age-related decline: Plasma concentration declines from approximately 200 ng/mL (10 M) at age 20 to roughly 80 ng/mL by age 60

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Endoplasmic reticulum stress in hepatic stellate cells promotes liver fibrosis via PERK-mediated degradation of HNRNPA1 and up-regulation of SMAD2

10.3382/ps/pez322 29 DuK.FanY.LiD

Label the vial with the peptide name, concentration, and date reconstituted