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EEG recordings were analyzed according to Rechtschaffen and Kales standardized criteria

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Average statistical power considering the effect size (percent improvement in physiologic function, sample number, and level of significance) was at least 72% in Cohort 1

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In some embodiments, high viscosity formulations or devices contain from about 10% to about 25% of a viscosity enhancing agent or viscosity modulating agent (e.g., gelling components such as polyoxyethylene-polyoxypropylene copolymers)