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In particular, reduced GST activity as compared to control subjects was described in all brain areas and ventricular CSF in postmortem AD patients, suggesting a role of these enzymes in the pathogenesis of the disease 51

Mechanistically, T-DXd enhances tumor antigen presentation and CD8 + T cell infiltration through ADCC and the bystander effect, providing an ample effector cell basis for ICIs to lift immune suppression, thereby creating synergistic amplification

31 , e80 (2017)