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N Engl J Med 2008;359:1577-89

The glucagonostatic and insulinotropic effects of glucagon-like peptide 1 contribute equally to its glucose-lowering action

In addition, in October 2024, AstraZeneca announced that it will discontinue marketing brand Byetta

They also decreased body weight, potentially contributing to mitigate the direct impact of obesity on CKD

Zepbound demonstrated 20.9% mean body weight reduction in SURMOUNT-1 at 15mg surpassing semaglutides 15% benchmark and establishing dual GIP/GLP-1 agonism as the dominant next-generation obesity mechanism