The capsule polysaccharide from serogroups A, B, C, W, and Y meningococci inhibits C1q interaction with bound anti-fHbp and anti-porin A antibodies, and, consequently, the deposition of C4b and classical complement pathway (Jarvis and Vedros, 1987), as well as LOS sialylation (Vogel et al., 1997), limits C3 deposition, inhibiting the alternative pathway
doi: 10.1016/j.virol.2018.07.011 72 PanDFloresOUmbachJLPesolaJMBentleyPRosatoPCet al
They wrote: Remarkably, under the optimized micelle conditions, A42 assembles into oligomers that insert into lipid bilayers as well-defined pores and adopt a specific structure with characteristics of a -barrel arrangement (Zhaliazka et al., 2023)
Approaches include redox interactions with high-valent metal ions (like Cu 2 and Fe 3 ), suppression of GSH synthesis using agents such as BSO, the use of nanozymes that mimic enzymatic activity, and direct GSH neutralization through molecular binding [18]
Talib, W