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Most patients notice reduced appetite within the first few days and may lose 3 to 5 pounds in the first week, much of which is water weight
Large-scale, randomized controlled trials with robust stratification of HFpEF phenotypes are needed to confirm the efficacy and safety of GLP-1RAs in this population
So, we need to look to less obvious mechanisms
For patients with a history of diverticulitis, this altered gut physiology introduces considerations that should be discussed with a healthcare provider before starting therapy
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