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For patients with obesity, the increased risk is even higher

When used under professional supervision, GLP-1 therapies can lead to clinically meaningful and sustainable weight loss , while also helping to manage metabolic health and reduce the risk of obesity-related conditions

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In adipocyte models, both primary cultures and immortalised lines document enhanced lipolysis and induction of thermogenic gene expression including UCP1, PGC-1, and CIDEA, markers of brown adipose tissue activation