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The key question with this high efficacy will be tolerability, and data so far showed some dose-dependent elevations of heart rate, which bear monitoring

Special thanks to Brendan Klinkenberg and Nina Feldman

In the TRIUMPH-4 Phase 3 trial disclosed by Lilly in March last year, the share of participants experiencing nausea over 68 weeks of treatment was 38.1% in the 9mg group and 43.2% in the 12mg group

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Some people naturally have variations in receptor sensitivity or downstream signalling pathways that reduce drug effectiveness