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Heart rate increases were not associated with adverse cardiac events in the trials, but it is something researchers monitor closely

p53-pS15 is a major focal point in p53 activation to mediate p53-dependent transcription or growth arrest, Ser 15 phosphorylation triggers a sequence of additional sites phosphorylation in p53 (including Ser9, -20, -46 and Thr18) that contribute further to p53 activation 28

It causes little irritation

At Harmony Health, it is offered in a clinical, supervised setting

Implementation studies examining how best to bring general clinical practice in line with expert guidelines would also lead to a better understanding of how to bridge treatment gaps. For more information: Sara Cromer, MD , can be reached at [email protected].