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Pinch the skin slightly around the injection site to create a small fold of skin

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This approach was taken given that PYY(336) is readily truncated or modified at the N-terminal region without loss of NPY2R agonism 54,55 , and that modification of the N-terminal region of exendin-4 produces antagonists of the GLP1-R 47 , yet the C-terminal hexapeptide is not critical for GLP1-R agonism 56

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