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The supplement has been restricted in England and other European countries due to what one paper characterized as "an unacceptable risk" of liver toxicity

Glutamate and mitochondria: Two prominent players in the oxidative stress-induced neurodegeneration

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Other peptides under investigation Several additional peptides are being studied for disc-related applications, though with less established evidence: Vasoactive Intestinal Peptide (VIP) has demonstrated the ability to slow disc degeneration progression and improve aggrecan levels in mouse studies

However, the medication discontinuation rates were greater than 50% across all doses compared to 40% with placebo, with the most common adverse events (AE) being gastrointestinal in nature [27]