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Comparison with Other COMT Inhibitors Drug Site of Action Liver Toxicity Notes Entacapone Peripheral only Low Most commonly used Tolcapone Peripheral + CNS High Requires liver monitoring Opicapone Peripheral Low Long-acting, once daily --- 11

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About 1 mg of iron is lost each day through sloughing of cells from skin and mucosal surfaces, including the lining of the gastrointestinal tract (Cook et al., 1986)

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Nieman, Colin Kay, Robert ODonnell, Alessandra Pecorelli, Marissa Kinney, Yanyan Li, Suzanne L