free-drug occupancy method (albumin Kd 1.86 uM, free fraction 0.29%): Willard JCI Insight 2020
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Hydrogen peroxide inducible clone-5 mediates reactive oxygen species signaling for hepatocellular carcinoma progression
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Another study incorporated Melittin, a typical AMP, into monolayer perfluorocarbon nanoparticles, which was verified to enhance the retention time of Melittin in vivo, prevent the peptide from being hydrolyzed by serum proteases, and significantly reduce the hemolytic toxicity of Melittin in vivo