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Long-term safety is still being studied, though semaglutide has demonstrated cardiovascular benefit in trials, while tirzepatides long-term cardiovascular outcomes are under evaluation

And some patients report sexual side effects that are rarely discussed in marketing materials

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The FDA states that state boards of pharmacy generally hold primary responsibility for day-to-day oversight of state-licensed pharmacies that are not registered as outsourcing facilities, and that the FDA conducts surveillance and for-cause inspections of those pharmacies