Semaglutide, delayed gastric emptying, and intraoperative pulmonary aspiration: A case report
NICE and MHRA guidance recommend monitoring for gastrointestinal side effects and reporting adverse reactions through the Yellow Card scheme
It has recently been shown that GLP-1R neurons in the dorsomedial hypothalamic nucleus regulate pancreatic activity by affecting the dorsal motor nucleus of the vagus, specifically lowering blood glucose levels by increasing insulin release (Huang et al., 2022)
Dungan KM, Povedano ST, Forst T, Gonzalez JG, Atisso C, Sealls W, et al
In December 2025, Eli Lilly announced positive topline results from TRIUMPH-4 a 68-week Phase 3 trial in adults with obesity and knee osteoarthritis in which retatrutide delivered average weight loss of up to 71.2 lbs alongside substantial reductions in osteoarthritis pain