Individual ingredient research is more promising: caffeine and capsicum have demonstrated modest metabolism-boosting effects (around 50-100 extra calories burned per day), chromium may help reduce sugar cravings, and fiber-rich nopal can promote satiety
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Gerli S, Della Morte C, Ceccobelli M, et al
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During I/R injury, gut-derived endotoxins such as lipopolysaccharide (LPS) can translocate from the gut into the systemic circulation, triggering inflammation and immune activation (Suganya and Koo, 2020