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Absolutely, and this is precisely why GGT is such a powerful longevity marker

(ii) GxG (Gene x Gene) interaction, wherein the loss of two genes leads to a fitness phenotype that is not the simple additive sum of two single KOs, and (iii) GxGxE (Gene x Gene x Environment) interaction, wherein the impact of the pairwise genetic interaction is dependent on the metabolic state

At Pure Med Spa Chicago , we believe in treating the whole person

PMID: 40658418, PMCID: PMC12261005, DOI: 10.1001/jamanetworkopen.2025.20498

By restoring cellular methyl donor capacity, it may support genomic stability and longevity-associated gene expression patterns