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The peptide binds GHRH receptors on anterior pituitary somatotroph cells, activates adenylyl cyclase to increase intracellular cAMP, enhances transcription of the GH gene, and stimulates exocytosis of stored GH from secretory granules

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With patience, minor lifestyle adjustments, and the proper guidance, these symptoms typically become easier to manage or disappear altogether

Patients who titrate aggressively (low to max dose in 16-20 weeks) usually end the first year at a higher average than patients who slow-walk titration