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GLP-1RAs and SGLT2is also provide sustained weight loss via different mechanisms

Notably, in a recent umbrella review of 14 meta-analyses, assessing pro/synbiotics on weight changes, most studies revealed a decrease in BMI and/or weight, favoring pro/synbiotics compared with placebo (26)

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Additional populations comprise specialized anti-adipogenic, profibrotic, inflammatory, and fibroblast-like ASPCs