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Reactive oxygen species (ROS), together with reactive nitrogen species (RNS), represent the most important prooxidants whose excessive accumulation leads to oxidative stress (OxS) and molecular damage ( ROS are crucial in thyroid function because they are essential in the initial stages of thyroid hormone synthesis during iodide oxidation ( Aerobic organisms have evolved multiple antioxidant and repair systems for protection against OxS

J Physiol Pharmacol 60(Suppl 7):115122 Tkalcevic VI, Cuzic S, Brajsa K, Mildner B, Bokulic A, Situm K, Perovic D, Glojnaric I, Parnham MJ (2007) Enhancement by PL 14736 of granulation and collagen organization in healing wounds and the potential role of egr-1 expression

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doi: 10.1016/j.it.2013.07.006 61 IngRStevensonMM

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