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The GLP-1R can couple to the Gs or Gq proteins, leading to increases in intracellular cAMP and/or Ca2+ levels and activation of PKA, Epac-2, phospholipase C and ERK1/2 signal transduction pathways

Clinical and subjective measures Depression Depressive symptoms were assessed with the clinician-rated MontgomeryAsberg Depression Rating Scale (MADRS) as the primary measure, together with the self-report Quick Inventory of Depressive SymptomatologySelf Report (QIDSSR) and the Maudsley 3-item Depression Visual Analogue Scale (M3VAS)

Your provider can review your labs, discuss your goals, and determine whether a combination protocol is appropriate for you specifically

doi: 10.1007/s00726-018-2609-4

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