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Specifically, the gut microbiota acts as a metabolic bridge: it ferment dietary nutrients to produce bioactive metabolites (e.g., SCFAs, tryptophan derivatives), which signal to the brain via three pathways: 1

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Glucose is actively transported into the cell and is catalyzed into glucose-6-phosphate (G6P) by hexokinases (HKs)

2-hydroxynicotinic acid (2-OHNA) inhibits NAPRT by binding to its active site, preventing the conversion of NA to NAD +