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13 Further research is needed to investigate the interconnected pathophysiologic roles of glucagon, GLP-1, and GIP while determining the niche for twincretin therapy in T2DM

Metformin, if not contraindicated, is the preferred first line pharmacological agent for type 2 diabetes 14

Some common GLP-1 brand names include Ozempic, Wegovy, Mounjaro and Zepbound

As a Brand Promoter income opportunity, the evidence is clearer: most promoters earn little or nothing after product costs, the DSSRC found the income claims made by Le-Vel and its promoters to be atypical and insufficiently disclosed, and the structural dynamics of MLM income mean results are heavily concentrated among a small top tier

Subsequently, in the large randomised placebo-controlled FIDELIO-DKD trial including adults with type 2 diabetes and CKD, finerenone reduced the risk of the primary kidney outcome (a composite of kidney failure, sustained eGFR decline 40% or kidney death) by ~20% [69]