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In animal models of neurodegenerative disease, activation of TGR5 receptor was neuroprotective, decreasing neuronal death and inflammatory response (Monteiro-Cardoso et al., 2021)
Bacterial GSTs are implicated in a variety of distinct processes such as the biodegradation of xenobiotics, protection against chemical and oxidative stresses and antimicrobial drug resistance
Cho HY, Jedlicka AE, Reddy SP, Kensler TW, Yamamoto M, Zhang LY, Kleeberger SR: Role of NRF2 in protection against hyperoxic lung injury in mice
Without sufficient antioxidant defenses, toxins and oxidative stress can accumulate
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