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They resemble common medications like aspirin in structure and naturally resist stomach acid and digestive breakdown

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Method Enzym 473:4176 Gordon CJ (2005) Temperature and toxicology

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In that data, tirzepatide met the prespecified noninferiority bar versus the active comparator (dulaglutide) for major cardiovascular events but did not achieve statistical superiority (event rates were 12.2% vs 13.1%, HR 0.92, 95.3% CI 0.831.01, P=0.09), meaning tirzepatides cardiovascular safety was at least as good as an established GLP-1 medication