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Activation of TLRs exerts phagocytosis, inflammatory cytokine release, and complement activation (41, 42)

Semaglutide, a GLP-1 receptor agonist medication, has been studied as an option for individuals struggling with obesity and weight loss resistance

Its unique mechanism of action targets both GIP and GLP-1 receptors, setting it apart from other peptides that focus on single pathways

Targets and potential targets of MASH drugs

Potential for Dependence: While not inherent, some individuals may experience a degree of dependence, highlighting the need for careful tapering under medical supervision if treatment is discontinued