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Peer-reviewed clinical trials in the T4 family (RGN-259 ophthalmic, RGN-352 cardiac) used full-length T4

They can appear anywhere on the body, including the palms, soles, and mucosal surfaces

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Indirect comparisons through network meta-analyses conclude that SGLT2i ensure a greater protection than GLP-1RA against DKD progression [16,17,18]

Growing awareness of the long-term complications of uncontrolled diabetes, like neuropathy and cardiovascular disease, is also a critical aspect which further drives the demand for GLP-1 analogues