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Direct effects on sperm are still uncertain: a few 2025 trials showed modest gains in sperm morphology, but the human evidence remains thin and mixed

Meet the expert: Chloe Tsang , DMD, is a dentist at Tend in New York City

Across models spanning tendons, ligaments, muscle, bone and the GI (gastrointestinal) tract, the same core mechanisms appear repeatedly, which is either a sign of genuine pleiotropic biology or publication bias

Serious risks (rare): Pancreatitis, gallbladder issues, or thyroid tumors in people with certain genetic conditions

In addition, the development of acute respiratory distress syndrome (ARDS) may cause 5% of Covid-19 patients to become critically ill and require persistent breathing (Al-kuraishy et al