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59,61,65 For example, saturating the system with administered tamoxifen results in a blockade of natural estrogen action on the regulation of gonadotropins by the pituitary-hypothalamic axis and inhibition of breast cancer cell division, while inducing growth of the uterine endometrial cells

The researchers developed a strain of mice that totally lacked this gene in order to study what happens when its missing

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Vunta et al., 2007

WAT expands through hyperplasia, an increase in adipocyte cell number through precursor cell differentiation via a process termed adipogenesis, and hypertrophy, an increase in existing, mature adipocyte cell size